The Translational Neurology and Neurophysiology Laboratory (NODO Lab) at the University of Chile is primarily dedicated to conducting clinical and translational research aimed at understanding the pathophysiological mechanisms and identifying novel biomarkers of neurological diseases—particularly Motor Neuron Disease (ALS) and other neurodegenerative and neuromuscular disorders.

To achieve this, we employ multimodal neurophysiological techniques to investigate both the central and peripheral nervous systems. These are integrated with structural and functional imaging, as well as molecular biomarker analysis. Our ultimate goal is to advance the understanding of the mechanisms that drive these neurological conditions, improve diagnostic and monitoring tools, and actively participate in clinical trials for novel therapies in Chilean patients.

Additionally, we are interested in combining clinical research with the training of new subspecialist in the area of clinical neurophysiology (e.g. EMG and intraoperative neurophysiological monitoring - MNIO) and/or neuromuscular diseases.